Maciel Prenatal Interpreter 10

MPI 10’s Patients view

Maciel Prenatal Interpreter (MPI) is a software system for identifying fetuses at risk for open neural tube defects (ONTD), Down Syndrome, trisomy 18, and Smith-Lemli-Opitz Syndrome (SLOS) using established methods.

MPI provides a total management system that allows you to do everything quickly and accurately – your way – using your ID numbers, test units and cutoffs. Ours is the system of choice of over 575 prenatal programs, in more than 35 countries, and a dozen state-run US programs for more than twenty years.


  • Flexible and easy to use, with complete online help and detailed error checking
  • Complete sample accessioning
  • Identifies fetuses at risk for open neural tube defects (ONTD), Down Syndrome, trisomy 18, trisomy 13, and Smith-Lemli-Opitz Syndrome (SLOS) using established methods with your cutoffs
  • Supports screening in first and second trimester, integrated screening, and amniotic fluid analysis at any time
  • Calculates corrected multiples of the median (MoMs) for serum AFP, hCG, uE3, inhibin, ITA/h-hCG, PAPP-A, PlGF, and fluid AFP
  • Adjusts for ultrasound markers: nuchal translucency (NT), DVPI, and nasal bone present/absent
  • Freely add comments to samples
  • Calculates twin risks, combination race code/diabetic/multiple gestation cutoffs
  • Dated median tables – your past medians stay on file
  • Gestational age by LMP, physical exam, ultrasound, EDD, or IVF
  • Racial median tables – each demographic group can have its own table; no need to use correction factors; old tables stay on file
  • Weight correction for each race code/substance; correction by log-linear or linear-reciprocal
  • Issues interpretive reports with wording fully under your control, including graphs and color-coding
  • Print reports to PDF or paper; save modified reports
  • Offers an extensive menu of reports
  • Interfaces with most Laboratory Information Systems (LIS)
  • Calculates raw and regressed medians based on your patient data for each substance
  • Validation procedure ensures correct operation
  • Multi-level access and password protection for restricting software use
  • Weight correction option; generate/check your own weight correction formula in a report

User-Configurable Parameters

  • Weight correction for all serum markers
  • Weight correction limits
  • Daily or weekly medians
  • Medians based on maternal age to the day or completed years
  • Many choices of statistical parameter sets for risk calculations
  • Up to four qualitative levels of AFP MoMs (low, normal, borderline, or elevated)

Sample Accessioning Features

  • Patient demographics include: birth date, maternal weight, race, insulin-dependent diabetic status, smoking status, history of NTD and FDS, IVF dates
  • Gestational age: you choose the calculation method to determine age
  • Sample data: includes date drawn & received, maternal serum or amniotic fluid sample
  • Plus: patient and physician’s name and address, family history and background, follow-up data
  • Group samples into batches to facilitate multi-user workflow

Interface Features

  • Data management interfaces enable test results to be entered automatically
  • Interfaces can automatically correct for diluted samples
  • LIMS: Laboratory Information Management System – a generic, unidirectional or bi-directional communication for downloading demographics and test requests and uploading results

Deployment options

  • Store your data where it works for you – on the workstation, network share, or a database server
  • Database server deployment allows simultaneous data entry from multiple workstations.